Association of biochemical and clinical parameters with parathyroid adenoma weight. Turkish-Bulgarian endocrine and breast surgery study group, hyperparathyroidism registry study
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Primary hyperparathyroidism (pHPT) caused by a single benign parathyroid adenoma is a common endocrine disorder that is affected by regional differences. Living in different geographical regions reveals differences in the laboratory results and pathological findings, but studies on this subject are not sufficient. The article focuses on biochemical and pathological effects of geographical differences in parathyroid adenoma. In addition, the present study seeks to elaborate on treatment methods and effectiveness of screening in geographical area of Bulgaria and Turkey. METHOD: In this prospective study, 159 patients were included from 16 centres. Demographic characteristics, symptoms, biochemical markers and pathologic characteristics were analysed and compared between 8 different regions. RESULTS: Patients from Turkish Black Sea had the highest median serum calcium (Ca) level, whereas patients from Eastern Turkey had the lowest median serum phosphorus (P) level. On the other hand, there was no significant difference between Ca, parathormone (PTH) and P levels according to regions. Patients from Eastern Turkey had the highest adenoma weight, while patients from Bulgaria had the lowest adenoma weight. The weight of adenoma showed statistically significant differences between regions (p < 0.001). There was a correlation between adenoma weight and serum PTH level (p = 0.05) and Ca level (p = 0.035). CONCLUSION: This study has provided a deeper insight into the effect of the regional differences upon clinicopathological changing and biochemical values of pHTP patients with adenoma. Awareness of regional differences will assist in biochemical screening and treatment of this patient group.
Source: Asian Journal of Surgery
Authors: Beyza Özçınar, Gizem Öner, Özer Makay, Aykut Soyder, N. Zafer Cantürk, M. Ümit Uğurlu, Y. Atakan Sezer, Semih Görgülü, Mustafa Girgin, A. İbrahim Özemir, Serdar Özbaş, Bülent Ünal, Rumen Pandev, Serap Erel, A. Uğur Emre, A. İlker Filiz, M. Nuran Akçay, Salih Demircioğlu, S. Ata Güler, Erkan Öztürk, Ramazan Yıldız, Güldeniz Karadeniz Çakmak, Yavuz Kurt, Yeşim Erbil, Bahadır M. Güllüoğlu
Institutions: Istanbul University-Cerrahpaşa, Istanbul University, University of Antwerp, Antwerp University Hospital, Kocaeli Üniversitesi, Ege University, Adnan Menderes University, Marmara University, Trakya University, Gülhane Eğitim ve Araştırma Hastanesi, Fırat University, Istanbul Medeniyet University, Inonu University, Queen Giovanna Hospital, Ankara Eğitim ve Araştırma Hastanesi, Zonguldak Bülent Ecevit University, Atatürk University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,200
OpenAlex ID: W3190552285