Year: 2021
Type: review
Abstract: Both obesity and aging are associated with the development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of these diseases. Obesity and aging trigger adipose tissue alterations that ultimately lead to a pro-inflammatory phenotype of the adipose tissue-resident immune cells. Obesity and aging also share other features such as a higher visceral vs. subcutaneous adipose tissue ratio and a decreased lifespan. Here, we review the common characteristics of obesity and aging and the alterations in white adipose tissue and resident immune cells. We focus on the adipose tissue metabolic derangements in obesity and aging such as inflammation and adipose tissue remodeling.
Source: Biochemical Pharmacology
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,700
Funders: Fundació la Marató de TV3, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Comisión Nacional de Investigación Científica y Tecnológica, Instituto de Salud Carlos III, European Regional Development Fund
OpenAlex ID: W3190760415