Work

An Insulin Resistance Score Improved Diabetes Risk Assessment in the Malmö Prevention Project—A Longitudinal Population-Based Study of Older Europeans

Year: 2021

Type: article

Abstract: The worldwide prevalence of type 2 diabetes (T2D) continues to increase, despite the established efficacy of T2D prevention interventions. Identifying individuals at high risk and making them the focus of preventive interventions may reduce the incidence of diabetes and global disease burden. We recently showed that T2D risk assessment in white middle-aged men and women can be improved with addition of an insulin resistance measure (assessed by HOMA of insulin resistance) to glycemia and other established risk factors (1). We have also developed an insulin resistance score (IRScore), comprising fasting insulin and C-peptide measured by mass spectrometry, to assess the probability of existing insulin resistance where insulin resistance was defined as being in the top tertile of steady-state plasma glucose level (≥198 mg/dL) (2). In the current study, we asked whether this IRScore improved T2D risk assessment beyond glycemia and established risk factors in a population of older Europeans. Older populations are of particular interest given the steady increase in the average age worldwide, especially in Europe, Japan, China, and the U.S. We conducted a case-cohort study based on the …

Source: Diabetes Care

DOI: 10.2337/dc21-1328

Authors: Dov Shiffman, Judy Z. Louie, James B. Meigs, James J. Devlin, Michael J. McPhaul, Olle Melander