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Recapitulation of Endogenous 4R Tau Expression and Formation of Insoluble Tau in Directly Reprogrammed Human Neurons

Year: 2021
Type: article
DOI: 10.1016/j.stem.2022.04.018
Authors: Lucia S. Capano, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji-Sun Kwon, Kyle F. Burbach, Nicolas R. Barthélemy, Susan G. Fox, Celeste M. Karch, Randall J. Bateman, Henry Houlden, Richard I. Morimoto, David M. Holtzman, Karen E. Duff, Andrew S. Yoo
Language: English
Subfield: Physiology
Field: Medicine
Open Access status: bronze
Funders: Eli Lilly and Company, Roche, Columbia University, Desert Research Institute, Cure Alzheimer's Fund, University of Washington, Institute of Clinical and Translational Sciences, Wellcome Trust, Edward Mallinckrodt, Jr. Foundation, Alzheimer's Society, Alzheimer’s Research UK, Eisai, National Institutes of Health, Alzheimer’s Disease Research Center, University of Washington, Alzheimer's Disease Research Center, University of Pittsburgh, Medical Research Council, National Institute on Aging, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Awards: Regulation of Peripheral Proteostasis, G1476475964, CNS TAU KINETICS IN ALZHEIMER'S DISEASE, G20300921, Differential vulnerability to tauopathy in Alzheimer's disease and Frontotemporal Lobe Dementia, G3455473179, Tau Kinetics in the human CNS in vivo and in vitro, G371566797, G3909736163, BCL-XL AND BCL-XS PROTEINS AND APOPTOSIS, G457810953, Mechanistic insights into neurodegeneration in Huntington's disease using patient-derived neurons through direct conversion of fibroblasts, Modeling Neuronal Aging and Alzheimer's Disease in Human Neurons Directly Converted from Fibroblasts, Targeting Tau Proteoforms in Frontotemporal Dementia, Training Program in Cellular and Molecular Biology, G647771723, Targeting Tau Proteoforms in Frontotemporal Dementia, G710411779, Healthy Aging and Senile Dementia, G7800193406, Proteostasis in Aging and Neurodegenerative Disease, G8310185830, G9000239624, G9000266300, Alzheimer's Disease Research Center, Washington University Institute of Clinical and Translational Sciences, Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study
OpenAlex ID: W4281653848
FWCI: 4.863
Cites: 98
Cited by: 65
Related to: 10