Krüppel-like factor 9 upregulates E-cadherin transcription and represses breast cancer invasion and metastasis.
Year: 2021
Type: article
Abstract: experiments confirmed that KLF9 strongly inhibited the lung metastasis of breast cancer and increased mouse E-cadherin expression in 4T1 mouse breast cancer cells. Taken together, our findings demonstrated that KLF9 could suppress breast cancer invasion and metastasis by upregulating E-cadherin, which provided new insight into aggressive treatment of breast cancer by targeting the KLF9/E-cadherin axis.
Source: PubMed
Authors: Xiaoyan Bai, Xiao Jiang, Yuting Liu, Yiting Wang, Xuewei Jiang, Guang Song, Hongmei Qiu, Qinggao Zhang
Institutions: Dalian University, Dalian Municipal Central Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3192579031