Work

Evolution towards green radical generation in total synthesis

Year: 2021

Type: review

Abstract: The use of radicals as intermediates in total synthesis has evolved since their initial use in the latter half of the twentieth century. Radical generation from metal hydride methodologies has shifted to "greener" techniques including catalytic metal-mediated systems, electrochemical and photoredox-mediated processes. This review will focus on these classical and contemporary methods for radical generation and their applications in recent total syntheses.

Source: Chemical Society Reviews

DOI: 10.1039/d1cs00411e

Authors: Matthew S. Galliher, Bec J. Roldan, Corey R. J. Stephenson

Institution: University of Michigan

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Camille and Henry Dreyfus Foundation, University of Michigan, National Institute of General Medical Sciences

Awards: G532009735, Enabling Elucidation of the Biological Activity of Resveratrol Natural Products with Synthesis