Work

Melatonin effect on platelet count in patients with liver disease.

Year: 2021

Type: article

Abstract: AIM: A positive effect of melatonin on platelet count in patients with chronic liver disease is reported in the current study. BACKGROUND: , as an intrinsic hormone produced mainly by the liver, plays an important role in this complication induced by liver disease. METHODS: This research was a double-blind, cross-over, placebo-controlled pilot study. Patients with liver disease were given two 5-mg pearls of melatonin or a placebo for two weeks, and after a 2-week washout period, their groups were switched. Liver function tests and platelet counts were assessed once at the beginning and once at the end of each phase of the study. RESULTS: -value <0.05). CONCLUSION: Melatonin may increase platelet count and inhibit thrombocytopenia in patients with liver disease; however, more investigations are needed to confirm the current results.

Source: Gastroenterology and hepatology from bed to bench.

Authors: Ayda Esmaeili, Mohssen Nassiri Toosi, Mohammad Taher, Jaleh Bayani, Soha Namazi

Institutions: Urmia University, Urmia University of Medical Sciences, Tehran University of Medical Sciences

Language: English

Topic: Liver Disease and Transplantation

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Tehran University of Medical Sciences and Health Services

OpenAlex ID: W3193311185

FWCI: 0.47

Cites: 20

Cited by: 4

Related to: 10