Year: 2021
Type: article
Abstract: Diabetes mellitus is a major public health problem worldwide. This endocrine disease is clustered into distinct subtypes based on the route of development, with the most common forms associated with either autoimmunity (T1DM) or obesity (T2DM). A shared hallmark of both major forms of diabetes is a reduction in function (insulin secretion) or mass (cell number) of the pancreatic islet beta-cell. Diminutions in both mass and function are often present. A wide assortment of plants have been used historically to reduce the pathological features associated with diabetes. In this review, we provide an organized viewpoint focused around the phytochemicals and herbal extracts investigated using various preclinical and clinical study designs. In some cases, crude extracts were examined directly, and in others, purified compounds were explored for their possible therapeutic efficacy. A subset of these studies compared the botanical product with standard of care prescribed drugs. Finally, we note that botanical formulations are likely suspects for future drug discovery and refinement into class(es) of compounds that have either direct or adjuvant therapeutic benefit.
Authors: Peter Smoak, Susan J. Burke, J. Jason Collier
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,780
Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Complementary and Alternative Medicine, National Institute of Neurological Disorders and Stroke, National Center for Complementary and Integrative Health
Awards: SGK1 is a regulator of islet beta cell mass and secretory function, Astrocytes, Glucose Detection, and Counter-Regulation, A Unique Receptor Agonist Approach for Type 1 Diabetes Prevention, Glial-Neural Interactions in Autonomic Control, G7572694725, G7585954874, Development of Mice with Conditional ICAM-1 Deletion, Botanical Approaches to Combat Metabolic Syndrome, Metabolic Basis of Disease - Phase 2
OpenAlex ID: W3193652841