Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates
Year: 2021
Type: editorial
Abstract: Aging across the Primate Order is poorly understood because ages of individuals are often unknown, there is a dearth of aged animals available for study, and because aging is best characterized by longitudinal studies which are difficult to carry out in long-lived species. The human population is aging rapidly, and advanced age is a primary risk factor for several chronic diseases and conditions that impact healthspan. As lifespan has increased, diseases and disorders of the central nervous system (CNS) have become more prevalent, and Alzheimer's disease and related dementias have become epidemic. Nonhuman primate (NHP) models are key to understanding the aging primate CNS. This Special Issue presents a review of current knowledge about NHP CNS aging across the Primate Order. Similarities and differences to human aging, and their implications for the validity of NHP models of aging are considered. Topics include aging-related brain structure and function, neuropathologies, cognitive performance, social behavior and social network characteristics, and physical, sensory, and motor function. Challenges to primate CNS aging research are discussed. Together, this collection of articles demonstrates the value of studying aging in a breadth of NHP models to advance our understanding of human and nonhuman primate aging and healthspan.
Source: American Journal of Primatology
DOI: 10.1002/ajp.23309
Language: English
Topic: Primate Behavior and Ecology
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Awards: G1172004040, Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and Symptomatology, Wake Forest Clinical and Translational Science Award, Wake Forest Alzheimer's Disease Core Center, Sex differences in cognitive and brain aging: a primate model, G3798839418, Behavioral and Neural Indicators of Prodromal Alzheimer's Disease, G76888958, G8157601638, Effects of Western and Mediterranean Diets on Metabolic and Neuropathologic Risk Factors for Alzheimer's Disease in Nonhuman Primates, Vervet Research Colony as a Biomedical Resource, Wake Forest Claude D. Pepper OAIC - Renewal, Translational Training in Aging and Alzheimer’s Disease Related Disorders
OpenAlex ID: W3193871536