Per- and polyfluoroalkyl substances and sleep quality among reproductive-aged Black women
Year: 2021
Type: conference-abstract
Abstract: BACKGROUND AND AIM: High concentrations of per- and polyfluoroalkyl substances (PFAS) have been associated with sleep disturbances, but studies are limited. Black women have disproportionately higher concentrations of some PFAS and report a greater prevalence of sleep disturbances. METHODS: We assessed the association between plasma PFAS concentrations and poor sleep quality among 871 participants from the ongoing Study of Environment, Lifestyle, and Fibroids, a Detroit-area prospective cohort study of Black women recruited during 2010-2012. Using liquid chromatography-tandem mass spectrometry, we measured PFAS in non-fasting plasma collected at the baseline visit, including MeFOSAA, PFDA, PFHxS, PFNA, PFUnDA, PFOA, and PFOS. At the 80-month follow-up visit, participants completed the validated Pittsburgh Sleep Quality Index (PSQI). We used modified Poisson regression models to estimate risk ratios (RRs) and 95% confidence intervals (CIs) for associations, after adjusting for the following baseline covariates (identified from directed acyclic graphs and literature): age, income, body mass index, cigarette smoking, education, heavy menstrual bleeding, oral contraceptive use, parity, and time since last birth. RESULTS:Poor sleep quality (PSQI5) was reported by 61% of women. RRs comparing PFDA concentrations of 0.2, 0.3-0.4, and ≥0.5 ng/ml with 0.2 ng/ml were 1.09 (95% CI: 0.94-1.27), 1.26 (95% CI: 1.06-1.49) and 1.11 (95% CI: 0.96-1.28), respectively. Little association was observed with other PFAS. Among nulliparous women (n=334, with 58% PSQI5), RRs were elevated for those with higher concentrations of PFNA (≥1.0 vs. 0.6 ng/ml: RR=1.25, 95% CI: 0.96-1.64), PFDA (≥0.5 vs. 0.2 ng/ml: RR=1.17, 95% CI: 0.92-1.49), PFOA (≥2.3 vs. 1.3 ng/ml: RR=1.24, 95% CI: 0.95-1.61), and PFOS (≥9.0 vs. 4.2 ng/ml: RR=1.26, 95% CI: 0.98-1.60). CONCLUSIONS:We found no strong associations between PFAS exposure and poor sleep quality overall, except for PFDA. Among nulliparous women, greater concentrations of PFNA, PFDA, PFOA, and PFOS were positively associated with poor sleep quality, with PFOA and PFOS displaying dose-response associations. KEYWORDS: chemical exposures, endocrine disrupting chemicals, epidemiology, female, PFAS
Source: ISEE Conference Abstracts
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W3193983207