Risk Factors for Illness Severity Among Pregnant Women With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 Infection—Surveillance for Emerging Threats to Mothers and Babies Network, 22 State, Local, and Territorial Health Departments, 29 March 2020–5 March 2021
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Pregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with COVID-19 are limited. This study aimed to determine risk factors associated with COVID-19 illness severity among pregnant women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: Pregnant women with SARS-CoV-2 infection confirmed by molecular testing were reported during 29 March 2020-5 March 2021 through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). Criteria for illness severity (asymptomatic, mild, moderate-to-severe, or critical) were adapted from National Institutes of Health and World Health Organization criteria. Crude and adjusted risk ratios for moderate-to-severe or critical COVID-19 illness were calculated for selected demographic and clinical characteristics. RESULTS: Among 7950 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 25 years and older, healthcare occupation, prepregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions. CONCLUSIONS: Older age and having underlying medical conditions were associated with increased risk of moderate-to-severe or critical COVID-19 illness among pregnant women. This information might help pregnant women understand their risk for moderate-to-severe or critical COVID-19 illness and can inform targeted public health messaging.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciab432
Authors: Romeo R Galang, Suzanne M Newton, Kate R Woodworth, Isabel Griffin, Titilope Oduyebo, Christina L Sancken, Emily O’Malley Olsen, Kathryn Aveni, Heather Wingate, Hanna Shephard, Chris Fussman, Zahra S Alaali, Kristin Silcox, Samantha Siebman, Umme-Aiman Halai, Camille Delgado Lopez, Mamie Lush, Ayomide Sokale, Jerusha Barton, Ifrah Chaudhary, Paul H Patrick, Levi Schlosser, Bethany Reynolds, Nicole Gaarenstroom, Sarah Chicchelly, Jennifer S Read, Leah de Wilde, Deborah Mbotha, Eduardo Azziz-Baumgartner, Aron J Hall, Van T Tong, Sascha Ellington, Suzanne M Gilboa, Jennifer Beauregard, Jason Hsia, Kellianne King, Jean Ko, Elizabeth Lewis, Susan Manning, Varsha Neelam, Mirna Perez, Emily Petersen, Megan Reynolds, Aspen Riser, Maria Rivera, Nicki Roth, Regina Simeone, John Sims, Ashley Smoots, Margaret Snead, Penelope Strid, Diana Valencia, Bailey Wallace, Tineka Yowe-Conley, Laura Zambrano, Lauren Zapata, Amanda Akosa, John F Nahabedian, Amitsingh Rathore, Neha Shinde, Veronica Burkel, Dena Cherry, Daniel Chang, Charise Fox, Emily Reeves, Ayzsa Tannis, Susanna Trost
Institutions: Centers for Disease Control and Prevention, New Jersey Department of Health, Tennessee Department of Health, Massachusetts Department of Public Health, Michigan Department of Health and Human Services, New York State Department of Health, Maryland Department of Health, Minnesota Department of Health, Los Angeles County Department of Public Health, Puerto Rico Department of Health, Nebraska Department of Health and Human Services, Philadelphia Department of Public Health, Georgia Department of Public Health, Houston Health and Human Services Department, Oklahoma State Department of Health, North Dakota Department of Health, Pennsylvania Department of Health, Kansas Department of Health and Environment, University of Vermont, Vermont Department of Health, United States Virgin Islands Department of Health, Washington State Department of Health
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,052
Awards: G4330732107, G4611699547
OpenAlex ID: W3135584143