Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology
Year: 2021
Type: article
Abstract: While there has been an overall decline of tobacco and alcohol-related head and neck cancer in recent decades, there has been an increased incidence of HPV-associated oropharyngeal cancer (OPC). Recent research studies and clinical trials have revealed that the cancer biology and clinical progression of HPV-positive OPC is unique relative to its HPV-negative counterparts. HPV-positive OPC is associated with higher rates of disease control following definitive treatment when compared to HPV-negative OPC. Thus, these conditions should be considered unique diseases with regards to treatment strategies and survival. In order to sufficiently characterize HPV-positive OPC and guide treatment strategies, there has been a considerable effort to diagnose, prognose, and track the treatment response of HPV-associated OPC through advanced imaging research. Furthermore, HPV-positive OPC patients are prime candidates for radiation de-escalation protocols, which will ideally reduce toxicities associated with radiation therapy and has prompted additional imaging research to detect radiation-induced changes in organs at risk. This manuscript reviews the various imaging modalities and current strategies for tackling these challenges as well as provides commentary on the potential successes and suggested improvements for the optimal treatment of these tumors.
Source: Seminars in Radiation Oncology
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,050
Funders: National Science Foundation, Elekta, University of Texas Health Science Center at Houston, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, Health Science Center, University of Tennessee, University of Texas MD Anderson Cancer Center, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Institute of Dental and Craniofacial Research, Division of Mathematical Sciences, National Center for Advancing Translational Sciences
Awards: G1042170274, G109742339, G111615301, G120710122, G1398991385, G1442369977, G1468253849, G1858909031, G1881506306, G1901027039, G203557288, G2067572934, G2326049341, G2507610090, G2761087451, M D Anderson Cancer Center Head & Neck SPORE, G2816209679, G293715275, G3027680094, G3670257500, G380820829, G4262044161, G4275247141, G4287281526, G4660434062, G4839898642, G5410397277, G5458417383, G6540572259, G671808950, G6736661663, G7084632634, G7087022923, CCSG supplement: HOPE/CARE, G7400934742, G7568077175, QuBBD: Collaborative Research: SMART -- Spatial-Nonspatial Multidimensional Adaptive Radiotherapy Treatment, G8136034006, G8401789219, G842568704, G8736981740, G9000019672, G9000022405, G9000025114, G9000034222, G9000101031, G9000136543, G9000146054, G9000297587, Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy, G941367620, G9625747
OpenAlex ID: W3194497225