Work

Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?

Year: 2021

Type: review

Abstract: Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2021.722614

Authors: Bryan C. Hambley, Ciprian Tomuleasa, Gabriel Ghiaur

Institutions: University of Cincinnati, Iuliu Hațieganu University of Medicine and Pharmacy, Institute of Oncology Prof. Dr. Ion Chiricuta, Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950