Year: 2021
Type: preprint
Abstract: We consider the hypothesis that Evolution promotes population-wide genome patterns that, under randomization, ensures the External Validity of adaptations across population members. An adaptation is Externally Valid (EV) if its effect holds under a wide range of population genetic variations. A prediction following the hypothesis is that pairwise base substitutions in segregating regions must be 'random' as in Erdos-Renyi-Gilbert random graphs, but with edge probabilities derived from Experimental-Design concepts. We demonstrate these probabilities, and consequent mutation rates, in the full-genomes of 2504 humans, 1135 flowering plants, 1170 flies, 453 domestic sheep and 1223 brown rats.
Source: arXiv (Cornell University)
Author: Ribeiro, Andre F.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3195007269