Year: 2021
Type: review
Abstract: Anorexia nervosa (AN) is a serious and often fatal illness. Despite decades of research, investigators have failed to adequately advance our understanding of the biological aspects of AN that could inform the development of effective interventions. Genome-wide association studies are revealing the important role of metabolic factors in AN, and studies of the gastrointestinal tract are shedding light on disruptions in enteric microbial communities and anomalies in gut morphology. In this opinion piece, we review the state of the science through the lens of the clinical presentation of illness. We project how the integration of rigorous science in genomics and microbiology, in collaboration with experienced clinicians, has the potential to markedly enhance treatment outcome via precision interventions.
Authors: Cynthia M. Bulik, Ian M. Carroll, Phil Mehler
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $6,700
Awards: Microbiome-mediated weight, anxiety, and stress dysregulation in anorexia nervosa, Eating Disorders Genetics Initiative (EDGI), 1/7 Psychiatric Genomics Consortium: Finding actionable variation, G303339423, Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems Approach, Premorbid metabolism and growth in anorexia nervosa: A genetically informed exploration of risk, Predicting the multi-omic impact of psychiatric GWAS associations, G850050879, 1/7 PGC: Advancing Discovery and Impact, Nutrition Obesity Research Center (NORC)
OpenAlex ID: W3195330160