Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway
Year: 2021
Type: article
Abstract: Primary cytotoxic T cell lymphomas (CTCLs) are a rare subset of aggressive, poor-prognosis T-cell lymphomas targeting the skin; they include primary cutaneous γδT-cell lymphoma, primary cutaneous VD8+ aggressive epidermotropic T cell lymphoma (PCAETCL), and cytotoxic CTCL not otherwise specified. Lee et al report that all 3 subsets have JAK-STAT activation, but PCAETCL uniquely carries JAK2 gene fusions that may render them especially susceptible to JAK inhibitors.
Source: Blood
Authors: Katie Lee, Mark G. Evans, Lei Yang, Spencer Ng, Caroline Snowden, Michael Khodadoust, Ryanne A. Brown, Nicholas A. Trum, Christiane Querfeld, Linda T. Doan, Jinming Song, Hailing Zhang, Alejandro A. Gru, Gary S. Wood, David A. Wada, Vignesh Shanmugam, Paul L. Haun, Jon C. Aster, Lyn M. Duncan, Joan Guitart, David M. Weinstock, Valentina Nardi, Jaehyuk Choi
Institutions: Northwestern University, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Stanford Medicine, Stanford University, City Of Hope National Medical Center, University of California, Irvine, Moffitt Cancer Center, University of Virginia, University of Wisconsin–Madison, Huntsman Cancer Institute, University of Pennsylvania, Massachusetts General Hospital, Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Identifying Mechanisms Governing T Cell Diversity, Informed Combination Strategies for Peripheral T-cell Lymphomas, G3568097969, G5803999735, Skin Diseases Research Center at the University of Wisconsin, Targeting High-Risk Lymphoid Neoplasms, G7943491577, G9000087884, Northwestern University Skin Biology and Diseases Resource-based Center
OpenAlex ID: W3195977130