Work

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

Year: 2021

Type: article

Abstract: antibacterial activity. Collectively, our study provides a novel chemical biology and computational strategy to expedite the discovery of new-generation polymyxins against life-threatening Gram-negative 'superbugs'.

Source: Chemical Science

DOI: 10.1039/d1sc03460j

Authors: Xukai Jiang, Nitin A. Patil, Mohammad A. K. Azad, Hasini Wickremasinghe, Heidi Yu, Jinxin Zhao, Xinru Zhang, Mengyao Li, Bin Gong, Lin Wan, Wendong Ma, Philip E. Thompson, Kai Yang, Bing Yuan, Falk Schreiber, Lushan Wang, Tony Velkov, Kade D. Roberts, Jian Li

Institutions: Shandong University, Monash University, Soochow University, University of Konstanz, State Key Laboratory of Microbial Technology, The University of Melbourne

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Shandong University, Monash University, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development, Pharmacology of intrathecal/intraventricular polymyxins: A systems-based approach, G3329423717, Targeting pan-drug resistant (PDR) Gram-negative pathogens with novel antisense drug technology, G7328368384, Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’

OpenAlex ID: W3196081816

FWCI: 2.648

Cites: 46

Cited by: 24

Related to: 10