Work

PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue

Year: 2021

Type: article

Abstract: T cells to BCF and decreasing viral reservoirs in lymphoid tissue. This work has potential implications for the development of curative HIV strategies.

Source: Science Immunology

DOI: 10.1126/sciimmunol.abh3034

Authors: Sheikh Abdul Rahman, Bhrugu Yagnik, Alexander P. Bally, Kristen N. Morrow, Shelly Wang, Thomas H. Vanderford, Gordon J. Freeman, Rafi Ahmed, Rama Rao Amara

Institutions: Emory University, Emory National Primate Research Center, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Blocking type I interferon signaling to reverse T cell exhaustion and control HIV-1 reservoirs, T Cell Costimulatory Pathways: Functions and Interactions, Targeting PD-1 Pathway for Functional Cure of AIDS, B and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection, Center for AIDS Research at Emory University, Emory National Primate Research Center

OpenAlex ID: W3196390679

FWCI: 2.397

Cites: 59

Cited by: 43

Related to: 10