Year: 2021
Type: editorial
Abstract: Roles of Tumor-Recruited Myeloid Cells in Immune Evasion in CancerDuring tumor formation and progression, tumors develop an immunosuppressive and tolerogenic microenvironment.Tumor-associated myeloid cells, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) represent one of the major immunosuppressive components in the tumor.Tumor-recruited myeloid cells contribute to tumor growth by exerting profound immunosuppressive effects through inhibition of adaptive and innate anti-tumor immune responses, stimulation of tumor angiogenesis, and remodeling extracellular matrix.This Research Topic aims to provide a comprehensive overview of the tumorrecruited myeloid cell subsets, describe the immune function of MDSCs, TAMs, tumor-associated neutrophils, and review the novel approaches targeting myeloid cells to enhance anti-tumor immunity and improve the efficacy of cancer immunotherapy.Our collection of 12 manuscripts consists of 2 Original Research papers, 3 Mini-Reviews, and 7 Reviews are summarized below.This Research Topic covers different aspects of MDSCs biology, including their generation and mobilization in cancer, mechanisms of tumor-associated immune suppression, and their contribution to resistance to immunotherapy.Also, it highlights the novel approaches for targeting MDSCs in cancer.
Source: Frontiers in Immunology
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3196453196