Work

Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy

Year: 2021

Type: article

Abstract: A high-affinity antibody to LTBP4 stabilizes muscle and promotes improved muscle function in mouse models of muscular dystrophy.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.abf0376

Authors: Alexis R. Demonbreun, Katherine S. Fallon, Claire C. Oosterbaan, Lauren A. Vaught, Nina L. Reiser, Elena Bogdanovic, Matthew P. Velez, Isabella M. Salamone, Patrick G.T. Page, Michele Hadhazy, Mattia Quattrocelli, David Y. Barefield, Lauren D. Wood, J. Patrick Gonzalez, Carl Morris, Elizabeth M. McNally

Institution: Northwestern University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: FAILED REGENERATION IN THE MUSCULAR DYSTROPHIES: INFLAMMATION, FIBROSIS AND FAT, Myofilament proteins in cardiomyopathy and arrhythmias, Dose-specific responsiveness of glucocorticoid receptor-driven transcription in skeletal muscle, Regulating fibrosis and growth through latent TGFbeta binding proteins, Understanding and Improving Therapies for the Muscular Dystrophies, Myofilament proteins in cardiomyopathy and arrhythmias, Glucocorticoid and circadian clock coregulation of insulin sensitivity and metabolism

OpenAlex ID: W3196531443

FWCI: 1.803

Cites: 52

Cited by: 32

Related to: 10