Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
Year: 2017
Type: article
Abstract: Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
DOI: 10.1093/ije/dyx031
Authors: Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietiläinen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos CEM van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Cristina D’Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkilä, Tessa L Cutler, John L Hopper, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth JF Loos, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire MA Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Robert F Krueger, Matt McGue, Shandell Pahlen, Dorret I Boomsma, Thorkild IA Sørensen, Jaakko Kaprio, Karri Silventoinen
Institutions: University of Helsinki, University of the Basque Country, Osaka City University, Helsinki University Hospital, Mokpo National University, Vrije Universiteit Amsterdam, Ishikawa Prefectural Nursing University, Boston University, Istituto Superiore di Sanità, Colorado School of Public Health, Colorado State University, Duke University, Hebrew University of Jerusalem, Hadassah Medical Center, The University of Melbourne, Seoul National University, University College London, University of Colorado Boulder, Universitair Ziekenhuis Leuven, Ghent University Hospital, Icahn School of Medicine at Mount Sinai, Statens Serum Institut, Bandim Health Project, Odense University Hospital, Semmelweis University, Michigan State University, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, QIMR Berghofer Medical Research Institute, University of Ottawa, National Research Tomsk State University, Université Laval, Université du Québec à Montréal, Université de Montréal, Norwegian Institute of Public Health, Royal Children's Hospital, Murdoch Children's Research Institute, Karolinska Institutet, Hiroshima University, University of Bristol, MRC Integrative Epidemiology Unit, King's College London, Qingdao Municipal Center for Disease Control and Prevention, University of Minnesota, University of Copenhagen, Novo Nordisk Foundation, Frederiksberg Hospital, Bispebjerg Hospital, Novo Nordisk Foundation Center for Basic Metabolic Research, Finnish Institute for Health and Welfare, Institute for Molecular Medicine Finland, The University of Osaka
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,287
Funders: Michigan State University, Helsingin Yliopisto, Helsingin ja Uudenmaan Sairaanhoitopiiri, Bonnie Babes Foundation, Michigan State University Foundation, Cancer Research UK, University of Melbourne, ZonMw, Vrije Universiteit Amsterdam, Academy of Finland, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Novo Nordisk, State Government of Victoria, Ministerio de Ciencia e Innovación, Medical Research Council Canada, Novo Nordisk Fonden, Vlaamse regering, Diabetestutkimussäätiö, National Institutes of Health, Directorate for Biological Sciences, College of Engineering, Michigan State University, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Health and Medical Research Council, Japan Society for the Promotion of Science, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, FP7 Ideas: European Research Council, FP7 Health
Awards: G1075849409, G1108774313, G1110999434, G1224646995, G1311351439, G1393617006, G1409398652, The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty, G1520690021, G1569838456, G1680606931, G1698415274, G178382592, G1795780048, G1863377769, G1974109716, G2055575246, G2189011847, G2204220664, G2238725043, G2330461282, USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVE, G2367723459, G2382756871, G242423306, G2433343305, Hormones in Sex-different Developmental Psychopathology, A twin study of ovarian hormones and disordered eating, G2512784349, G2563833389, G2684863890, G279455444, G289688219, G2899750288, リンパ球の膜抗原と膜レセプター, G3077543175, Australian Centre of Excellence in Twin Research, G3127488624, Developmental Change in Temperament in Preschoolers: Implications and Etiology, G3250631134, G3333874486, Research Training - Genetics of Substance Abuse, G3368366672, G3404913481, G343291128, G357049385, Gene-environment Interactions in Childhood Conduct Problems, G3731392153, G3757293254, G3794989908, G3850253215, G3871240750, G387469706, G3969217981, Adolescent Alcohol Abuse: A Twin-Study Perspective, Determinants of Behavioral Development, Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors, G4367295956, G4374445680, G4381011041, International research project on physical growth and long-term prognosis in Twins and multiple births, G4411580604, G4446757277, G4460629988, G4536776401, G4542179381, HEALTH AND PSYCHOSOCIAL FACTORS IN OLDER BLACK TWINS, G4554940616, G4599390081, G463724992, G4682662344, G4757721458, Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics., G4879662331, G4924186877, スピネル型鉄酸化物の電極特性, G519084567, From the Child's Genes to Parental Environment and Back to the Child: Gene-environment Correlations in Early Social Development, G5349006154, G5471839915, G5522354678, G5612962370, Integrating contextual, proximal, and individual risks for child conduct problems, G5669758638, G5732418131, G5876242077, BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIES, G597584310, G6030094504, G626177176, G634521393, G6367764764, Spectral Energy Transfer in Rotating Turbulence, G6624723747, G6663973959, G6728033037, G70080636, G7031888331, G7142213720, G728996189, G7365436527, Adolescent Alcohol Abuse: A Twin-Study Perspective, G7583787834, G7624716486, 2-フッ化ピリジニウム塩を用いるテルペンアルコールの環化反応の研究, G7780068114, G7787549875, Genetic Influences on Activity Level in Early Childhood, G7916588302, G7956052275, G8034765632, Familial Transmission of Eating Pathology &Sex Hormones, G822877548, Predicting birth and early life outcomes, G8467350387, G858414785, G8590760118, G8729563425, G8880324339, G8966511090, How do we change from conception to birth?, G9000309104, G961365294, G96990336
OpenAlex ID: W2602572886