Work

Brønsted Acid Catalyzed Stereospecific Dearomative Spirocyclization of Benzothiophenyl Analogues of Tertiary cis-β-Benzylstyrenes

Year: 2022

Type: article

Abstract: 3-Substituted benzothiophenyl analogues of tertiary cis-β-benzylstyrenes undergo triflic acid-catalyzed dearomative spirocyclization to afford vicinal quaternary center-containing compounds at room temperature. Hydroarylation of the styrene is a competing process that could be selected for in substrates possessing electron-rich styrenyl alkenes, or an indole in place of the benzothiophene.

Source: Synlett

DOI: 10.1055/a-1894-8726

Authors: Benjamin J. Stokes, Anargul Tohti, Victoria Lerda

Institutions: Santa Clara University, University of California, Merced

Language: English

Topic: Organic and Inorganic Chemical Reactions

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Hellman Foundation

OpenAlex ID: W4284972476