Year: 2021
Type: editorial
Abstract: Growing evidence demonstrates that macroautophagy/autophagy in the host stroma influences the tumor microenvironment. We have uncovered that autophagy in host stromal fibroblasts is compulsory to initiate and maintain the desmoplastic fibrotic response that fosters mammary tumor progression. Genetic loss of fibroblast autophagy impedes COL1A/type 1 collagen secretion, which is required for the development of a stiff tissue matrix permissive for mammary tumor growth. As a result, stromal fibroblast autophagy deficiency impairs mammary tumor progression in vivo, even when the cancer cells themselves remain autophagy competent. Our results provide unique conceptual insight into how the autophagy pathway can be modulated to abolish the desmoplastic response required for cancer progression.
Source: Autophagy
Authors: Jenny A. Rudnick, Jayanta Debnath
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1304802053, Stromal Fibroblast Autophagy In Tumor Progression and Desmoplasia, G3780238105, G4119534169, G4677192102, Autophagy as a microenvironmental regulator of tumorigenesis and resistance, G5324093878, G5850682332, G6634643744, G734067297, Deciphering Autophagy-Dependent Secretion In Cancer Via Proximity-Based Biotinylation, Molecular and Cellular Mechanisms in Cancer, G8632625050, Autophagy and Pro-metastatic Differentiation, G913370977
OpenAlex ID: W3196901908