Work

Characterization of protein–ligand interactions by SABRE

Year: 2021

Type: article

Abstract: Protein–ligand binding interactions are characterized by the para -H 2 based hyperpolarization technique SABRE and flow-NMR. Binding to the protein is identified by R 2 change of a ligand first interacting with the Ir polarization transfer catalyst.

Source: Chemical Science

DOI: 10.1039/d1sc03404a

Authors: Ratnamala Mandal, Pierce Pham, Christian Hilty

Institution: Texas A&M University

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Science Foundation, Welch Foundation, Division of Chemistry

Awards: G1020944575, G6089863091, G672962523, Characterization of Macromolecular Dynamics Using Para-hydrogen Induced Polarization of Nuclear Spins