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Members of the miRNA-200 Family Regulate Olfactory Neurogenesis

Year: 2008
Type: article
Abstract: MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.
Source: Neuron
DOI: 10.1016/j.neuron.2007.11.018
Authors: Philip S. Choi, Lisa Zakhary, Wen-Yee Choi, Sophie Caron, Ezequiel Alvarez-Saavedra, Eric A. Miska, Mike McManus, Brian Harfe, Antonio J. Giraldez, Robert H. Horvitz, Alexander F. Schier, Catherine Dulac
Institutions: Howard Hughes Medical Institute, Harvard University, Massachusetts Institute of Technology, University of California, San Francisco, University of Florida, Yale University, Broad Institute, Harvard Stem Cell Institute
Language: English
Open Access status: hybrid
Estimated APC paid: $10,400
Awards: Functional genomics of neuronal identity., Genetic Mechanisms of Axis Formation in Vertebrates, G5964742504, G6408188552, MOLECULAR GENETICS OF SENSORY GANGLIA DEVELOPMENT, Genetic Mechanisms of Axis Formation in Vertebrates
OpenAlex ID: W2170697668
FWCI: 7.789
Cites: 65
Cited by: 245
Related to: 10