Work

Quantification of airway conductance from noninvasive ventilatory drive in patients with sleep apnea

Year: 2021

Type: article

Abstract: Classification of hypopneas as obstructive (decreased upper airway conductance) or central (decreased inspiratory flow commensurate with decreased effort) is complicated by the requirement of invasive methods, such as esophageal manometry. Here, we demonstrate that using a few esophageal pressure measurements to account for the interactions between inspiratory flow, pressure, and noninvasive ventilatory drive allows estimation of upper airway conductance. Further studies may use these findings to quantify airway obstruction completely noninvasively.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00387.2021

Authors: Thomas M. Tolbert, Ankit Parekh, Scott A. Sands, Anne M. Mooney, Indu Ayappa, David M. Rapoport

Institutions: Icahn School of Medicine at Mount Sinai, Brigham and Women's Hospital, Harvard University, Monash University

Language: English

Topic: Obstructive Sleep Apnea Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, American Thoracic Society, American Academy of Sleep Medicine, National Heart, Lung, and Blood Institute