Combining malaria vaccination with chemoprevention: a promising new approach to malaria control
Year: 2021
Type: article
Abstract: malaria vaccine and seasonal malaria chemoprevention led to a substantial reduction in clinical cases of malaria, severe malaria, and malaria deaths compared with the administration of either intervention given alone suggests that there may be other epidemiological/clinical situations in which a combination of malaria vaccination and chemoprevention could be beneficial. Some of these potential opportunities are considered in this paper. These include combining vaccination with intermittent preventive treatment of malaria in infants, with intermittent preventive treatment of malaria in pregnancy (through vaccination of women of child-bearing age before or during pregnancy), or with post-discharge malaria chemoprevention in the management of children recently admitted to hospital with severe anaemia. Other potential uses of the combination are prevention of malaria in children at particular risk from the adverse effects of clinical malaria, such as those with sickle cell disease, and during the final stages of a malaria elimination programme when vaccination could be combined with repeated rounds of mass drug administration. The combination of a pre-erythrocytic stage malaria vaccine with an effective chemopreventive regimen could make a valuable contribution to malaria control and elimination in a variety of clinical or epidemiological situations, and the potential of this approach to malaria control needs to be explored.
Source: Malaria Journal
Institutions: London School of Hygiene & Tropical Medicine, Tropical Diseases Research Centre, Université des Sciences, des Techniques et des Technologies de Bamako, Malaria Research and Training Center, Institut de Recherche en Sciences de la Santé, Kamuzu University of Health Sciences, Liverpool School of Tropical Medicine
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,490
Funders: Wellcome Trust, Medical Research Council
Awards: Epidemiological and statistical research on health problems of low and middle-income countries: MRC Tropical Epidemiology Group (TEG), Optimising seasonal malaria chemoprevention and seasonal vaccination in childhood to address the resurgent malaria burden in Africa, Intermittent Preventive Treatment with DHA-piperaquine for malaria in pregnancy in areas with high sulphadoxine-pyrimethamine resistance in Africa, A comparative trial of seasonal vaccination with the malaria vaccine RTS,S/AS01, seasonal malaria chemoprevention and the two interventions combined
OpenAlex ID: W3197587914