The combined effects of age and HIV on the anatomic distribution of cortical and cancellous bone in the femoral neck among men and women

Year: 2021

Type: article

Abstract: OBJECTIVE: To investigate HIV-related and age-related differences in hip bone structure in men and women. DESIGN: Cross sectional study of bone structure and HIV serostatus. METHODS: We used Quantitative Computed Tomography (QCT) data from the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) to examine cortical thickness (CT) and cortical (CBMD), trabecular (TBMD), and integral (IBMD) bone mineral density across anatomic quadrants of the femoral neck in older adult MSM and women with (PWH) and without (PWOH) HIV infection. The percentage difference (%diff) in the means for CT and BMD overall and by quadrant between PWH and PWOH were estimated. RESULTS: Among 322 MSM (median age 60 years) with bone measures, distributions were similar between HIV serostatus groups with %diff in the quadrant means ranging from -7 to -1% for CT and from -1 to 4% for BMD, and overall lower hip cortical thickness than expected. In contrast, in 113 women (median age 51 years), PWH had lower CT, IBMD and TBMD consistently across all quadrants, with differences ranging from -10 to -20% for CT, -6 to -11% for IBMD and -3 to -6% for TBMD. Estimates reached statistical significance in superoanterior quadrant for CT and IBMD and inferoposterior for CT. CONCLUSION: Among women, PWH appear to have a thinner cortex and less dense integral bone compared with PWOH, particularly in the superior quadrants whereas MSM overall had a thinner than expected hip cortex.

Source: AIDS

DOI: 10.1097/qad.0000000000003061

Authors: Alison G. Abraham, Jing Sun, Anjali Sharma, Michael T. Yin, J. Keenan Brown, Shadpour Demehri, Joshua Garza, Jayesh G. Shah, Frank J. Palella, Lawrence Kingsley, Beth D. Jamieson, Keri N. Althoff, Todd T. Brown

Institutions: Johns Hopkins University, University of Colorado Anschutz, University of Colorado Denver, Albert Einstein College of Medicine, Columbia University Irving Medical Center, Johns Hopkins Medicine, Northwestern University, University of Pittsburgh, University of California, Los Angeles

Language: English

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

OpenAlex ID: W3197944313