Work

Disrupted copper homeostasis: Pathogenic factor in autism spectrum disorder and side effect of valproic acid

Year: 2021

Type: article

Abstract: A 23 year old male diagnosed with autism spectrum disorder and treated with valproic acid presented with acute onset of hepatic failure; he died less than two months later. Laboratory studies led to a diagnosis of Wilson Disease. The case raised questions about a possible pathogenic role of disrupted copper homeostasis in ASD, and exacerbation of this disruption as a result of treatment with valproic acid. Screening for abnormalities of copper homeostasis may stimulate strategies for therapeutic targeting of a contributing etiological factor and avoidance of contraindicated medications.

Source: Personalized Medicine in Psychiatry

DOI: 10.1016/j.pmip.2021.100087

Authors: Stephen I. Deutsch, David R. Spiegel, Jessica A. Burket

Institutions: Eastern Virginia Medical School, Christopher Newport University

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,000