Platelets amplify endotheliopathy in COVID-19

Year: 2021

Type: article

Abstract: represents a promising candidate to reduce proinflammatory platelet-endothelial interactions. Together, these findings demonstrate a previously unappreciated role for platelets and their activation-induced endotheliopathy in COVID-19.

Source: Science Advances

DOI: 10.1126/sciadv.abh2434

Institutions: New York University, University of California, San Francisco, National Institutes of Health, National Cancer Institute, Center for Cancer Research, University of Pittsburgh, NYU Langone Health, Duke University, Duke Medical Center

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G1734361364, G1859754121, ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center, G2245350039, G3084026282, G3761063458, Control of Translation in Herpesvirus Infected Cells - Resubmission - 1, G5393666985, Virus Host Interactions that Regulate Translation in Cells Infected with HSV-1, G8177209986, EPITRANSCRIPTOMIC REGULATION OF CYTOMEGALOVIRUS INFECTION, Mechanistic Elucidation and Targeted Therapy of Organ Injury and Inflammation following Trauma

OpenAlex ID: W3198809089