The Mechanobiology of Vascular Remodeling in the Aging Lung
Year: 2021
Type: review
Abstract: Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
Source: Physiology
Institutions: Brigham and Women's Hospital, Mayo Clinic
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension, YAP/TAZ-mediated Mechanotransduction in Pulmonary Hypertension Pathogenesis, Targeting YAP/TAZ through non-canonical IK-B kinases for pulmonary hypertension, YAP/TAZ Regulation of TGF-beta/BMP Signaling and Vascular Remodeling in Pulmonary Arterial Hypertension
OpenAlex ID: W3199150019