Work

Inhibiting inflammasome; the possible mechanisms of action of azithromycin against COVID-19?

Year: 2021

Type: article

Abstract: Cytokine storm and destructive inflammation in the severe form of COVID-19 lead to acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), and dysfunction of several different body organs in patients. SARS-CoV-2 contains all inflammasome-activating proteins belonging to SARS-CoV and MERS-CoV viruses. Macrolides are known to possess immunomodulatory properties. Given the desirable results of azithromycin treatment for patients with a severe case of COVID-19, based on studies, it could be concluded that the immunomodulatory properties of azithromycin to inhibit inflammasome can help the treatment of patients with this disease.

Source: Journal of Preventive Epidemiology

DOI: 10.34172/jpe.2021.10

Authors: Ali Saeedi-Boroujeni, Mohammad Bahadoram, Bijan Keikhaei, Mohammad-Reza Mahmoudian-Sani, Azadeh Khayyat, Mohammad Ali Esmaeilpour

Institution: Ahvaz Jundishapur University of Medical Sciences

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Ahvaz Jundishapur University of Medical Sciences