Work

Comment on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”

Year: 2021

Type: editorial

Abstract: Break et al . (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and not to autoantibodies neutralizing interleukin-17 cytokines. We argue that both claims are not conclusively supported by their data and are at odds with 35 years of study.

Source: Science

DOI: 10.1126/science.abi5459

Authors: Anne Puel, Jean-Laurent Casanova

Institutions: Hôpital Necker-Enfants Malades, Howard Hughes Medical Institute, Inserm, Université Paris Cité, Human Genetic of Infectious Diseases, Institut des Maladies Génétiques Imagine, Rockefeller University

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Agence Nationale de la Recherche, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G1468374896, Lymphocyte T helper (Th) cell differentiation in patients with inborn errors of immunity to Mycobacterium and/or Candida species, G6337158721, Inborn errors of immunity underlying life-threatening COVID-19 in previously healthy patients, Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

OpenAlex ID: W3199749242

Cites: 15

Cited by: 12

Related to: 10