Work

Multienzyme nanoassemblies: from rational design to biomedical applications

Year: 2021

Type: review

Abstract: Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for multiple applications. Considerable progress has been made to design and fabricate MENAs in recent years. This review begins with an introduction of the up-to-date strategies in designing MENAs, mainly including substrate channeling, compartmentalization and control of enzyme stoichiometry. The desirable properties that endow MENAs with important applications are also discussed in detail. Then, the recent advances in utilizing MENAs in the biomedical field are reviewed, with a particular focus on biosensing, tumor therapy, antioxidant and drug delivery. Finally, the challenges and perspectives for development of versatile MENAs are summarized.

Source: Biomaterials Science

DOI: 10.1039/d1bm01106e

Authors: Di Li, Qirong Xiong, Li Liang, Hongwei Duan

Institutions: Jiangnan University, Nanyang Technological University, State Key Laboratory of Food Science and Technology

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Ministry of Education - Singapore, Ministry of Education, India, China Scholarship Council

Awards: G3670339161, G4320599555, G5350718487, G7241363003