Work

Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships

Year: 2021

Type: article

Abstract: Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in anticancer activity recently. Substituted groups in chemical structure play markedly important roles in biological activities. Therefore, the effective way to obtain lead compounds quickly is structural modification, which is guided by structure-activity relationships (SARs). This review presents the SAR of steroidal alkaloids and anticancer, including pregnane alkaloids, cyclopregnane alkaloids, cholestane alkaloids, C-nor-D-homosteroidal alkaloids, and bis-steroidal pyrazine. A summary of SAR can powerfully help to design and synthesize more lead compounds.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2021.733369

Authors: Ying Huang, Gen Li, Chong Hong, Xia Zheng, Haiyang Yu, Yan Zhang

Institutions: Shenyang Pharmaceutical University, Tianjin University of Traditional Chinese Medicine, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Language: English

Topic: Phytochemical Studies and Bioactivities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950