COVID-19 Critical Illness: A Data-Driven Review
Year: 2021
Type: review
Abstract: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges in critical care medicine, including extreme demand for intensive care unit (ICU) resources and rapidly evolving understanding of a novel disease. Up to one-third of hospitalized patients with COVID-19 experience critical illness. The most common form of organ failure in COVID-19 critical illness is acute hypoxemic respiratory failure, which clinically presents as acute respiratory distress syndrome (ARDS) in three-quarters of ICU patients. Noninvasive respiratory support modalities are being used with increasing frequency given their potential to reduce the need for intubation. Determining optimal patient selection for and timing of intubation remains a challenge. Management of mechanically ventilated patients with COVID-19 largely mirrors that of non-COVID-19 ARDS. Organ failure is common and portends a poor prognosis. Mortality rates have improved over the course of the pandemic, likely owing to increasing disease familiarity, data-driven pharmacologics, and improved adherence to evidence-based critical care.
Source: Annual Review of Medicine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1056612131, Optimization of LGM2605 for use as a device in lung transplant, G5514976981, G69771130, Mentored Patient Oriented Research in Lung Transplantation, Long Term Follow up of the Lung Transplant Outcomes Group Cohort, Training in Critical Care Health Policy Research, Cardiology and Pulmonary Clinical Research Training Program
OpenAlex ID: W3200718815