Work

Ultra-fast dynamic line-field optical coherence elastography

Year: 2021

Type: article

Abstract: In this work, we present an ultra-fast line-field optical coherence elastography system (LF-OCE) with an 11.5 MHz equivalent A-line rate. The system was composed of a line-field spectral domain optical coherence tomography system based on a supercontinuum light source, Michelson-type interferometer, and a high-speed 2D spectrometer. The system performed ultra-fast imaging of elastic waves in tissue-mimicking phantoms of various elasticities. The results corroborated well with mechanical testing. Following validation, LF-OCE measurements were made in in situ and in in vivo rabbit corneas under various conditions. The results show the capability of the system to rapidly image elastic waves in tissues.

Source: Optics Letters

DOI: 10.1364/ol.435278

Authors: Manmohan Singh, Alexander W. Schill, Achuth Nair, Salavat R. Aglyamov, Irina V. Larina, Kirill V. Larin

Institutions: University of Houston, Baylor College of Medicine

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Eye Institute, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Biomechanics of early mammalian cardiogenesis, In vivo analysis of mammalian fertilization, Center Core Grant for Vision Research, Optical Coherence Elastography of the Cornea