Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling
Year: 2019
Type: article
Abstract: This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent fashion. Increases in extracellular connective tissue occurred concomitantly with arterial remodeling. Wall thickness to lumen diameter ratios did not change in any vessel at any time when compared to controls, suggesting normalization of flow-induced wall stress through vascular remodeling.
DOI: 10.25777/3mza-eb82
Author: Tulis, David Anthony
Institution: Old Dominion University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3201236603