Work

Clinical Targeting of Altered Metabolism in High-Grade Glioma

Year: 2021

Type: article

Abstract: ABSTRACT: High-grade gliomas are among the deadliest of all cancers despite standard treatments, and new therapeutic strategies are needed to improve patient outcome. Targeting the altered metabolic state of tumors with traditional chemotherapeutic agents has a history of success, and our increased understanding of cellular metabolism in the past 2 decades has reinvigorated the concept of novel metabolic therapies in brain tumors. Here we highlight metabolic alterations in advanced gliomas and their translation into clinical trials using both novel agents and already established drugs repurposed for cancer treatment in an effort to improve outcome for these deadly diseases.

Source: The Cancer Journal

DOI: 10.1097/ppo.0000000000000550

Authors: Andrew J. Scott, Costas A. Lyssiotis, Daniel R. Wahl

Institutions: U-M Rogel Cancer Center, University of Michigan

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute