Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer
Year: 2021
Type: article
Abstract: Aberrant cell fate decisions due to transcriptional misregulation are central to malignant transformation. Histones are the major constituents of chromatin, and mutations in histone-encoding genes are increasingly recognized as drivers of oncogenic transformation. Mutations in linker histone H1 genes were recently identified as drivers of peripheral lymphoid malignancy. Loss of H1 in germinal center B cells results in widespread chromatin decompaction, redistribution of core histone modifications, and reactivation of stem cell-specific transcriptional programs. This review explores how linker histones and mutations therein regulate chromatin structure, highlighting reciprocal relationships between epigenetic circuits, and discusses the emerging role of aberrant three-dimensional chromatin architecture in malignancy.
Source: Cancer Research
Institutions: Rockefeller University, Weill Cornell Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: Damon Runyon Cancer Research Foundation, Samuel Waxman Cancer Research Foundation, Chemotherapy Foundation, Leukemia and Lymphoma Society, St. Jude Children's Research Hospital, Starr Foundation, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences
Awards: G1375395185, G1454828262, G1489452691, Role of novel onco-histone mutations in B-cell malignancies, Targeting Epigenetic Circuits in B-Cell Lymphomas, G3015188539, G3513532008, G4644098537, G493980436, G7457793036, G9000033147, G9000122234, The impact of changes in chromatin architecture on cancer phenotypes and tumor progression, G90082656, G953152894
OpenAlex ID: W3201974804