Work

Current strategies and technologies for finding drug targets of active components from traditional Chinese medicine

Year: 2021

Type: review

Abstract: Introduction: The ambiguity of the drug target is one of the major factors restricting the development of traditional Chinese medicine (TCMs) and its bioactive constituents. The characteristics of “multiple components, multiple targets and multiple pathways” of TCMs make the research of drug targets extremely difficult. With the emergence of new theories, there are increasing technologies and strategies that can be used for the drug targets research of TCMs. In this paper, we summarize several techniques and methods applied to the study of TCM targets. Methods: Through consulting a large number of literature, research and summary, and finally summarized the application direction of the technical method, advantages and limitations. Results: The methods and techniques including computer aided drug design, network pharmacology, phage display, affinity fishing, drug affinity responsive target stability and cellular thermal shift assay were summarized, and their application directions, advantages and disadvantages were discussed. At the same time, a large number of application examples were given to provide reference for the research of TCM targets.

Source: Frontiers in Bioscience-Landmark

DOI: 10.52586/4968

Authors: Feng Lu, Dan Wang, Ruo-Lan Li, Li-Ying He, Li Ai, Chun-Jie Wu

Institution: Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500