Work

Intravital assessment of precapillary pulmonary arterioles of type 1 diabetic mice shows oxidative damage and increased tone in response to NOS inhibition

Year: 2021

Type: article

Abstract: Diabetes pulmonary and microvascular consequences are well recognized but have not been characterized. We assessed lung microvascular changes in a live anesthetized mouse model of type 1 diabetes, using a novel intravital microscopy technique. Our results show new evidence that a diabetes-induced decrease in lung nitric oxide bioavailability underlies oxidative damage, enhanced platelet activation, and endothelial injury causing pulmonary microvascular dysfunction and altered vasoreactivity. These findings could provide novel strategies to prevent or reverse diabetes systemic consequences.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00395.2021

Authors: Andrew M. Roberts, Nayeem Z. Moulana, Rekha Jagadapillai, Lu Cai, Evelyne Gozal

Institution: University of Louisville

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Diabetes Association Research Foundation, University of Louisville, National Institute of Environmental Health Sciences