Year: 2021
Type: article
Study design: Case Report
Abstract: Introduction:The MTHFRC677T polymorphism is involved in several pathologies.Objectives: We report one case of headache associated with the MTHFR T677T genotype in a woman.Observation: A 39-year-old woman was admitted in neurology department on March 12, 2012 for headaches with feet and hands parathesia for several months.The physical examination had noted a decrease in osteotendinous reflexes and an abolition of the plantar cutaneous reflex.Hamilton's 17-item depression score was 7. In the etiological investigation of probable polyneuropathy, homocysteine was 88.39 μmol/l (standard < 15 μmol/l), folates 2.34 nmol/l (standard ≥ 11 nmol/l) and vitamin B 12 132 pmol/l (standard ≥ 147 pmol/l).The aetiological investigation of this hyperhomocysteinemia revealed an MTHFRT677T genotype. Conclusion:The MTHFRT677T genotype is associated with a variety of manifestations ranging from metabolic (B 12 deficiency), headache and polyneuropathies.
Source: Acta Scientific Neurology
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3202460647