Work

Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

Year: 2021

Type: article

Abstract: Water balance, tracked by extracellular osmolality, is regulated by feedback and feedforward mechanisms. Feedback regulation is reactive, occurring as deviations in osmolality are detected . Feedforward or presystemic regulation is proactive, occurring when disturbances in osmolality are anticipated . Vasopressin (AVP) is a key hormone regulating water balance and is released during hyperosmolality to limit renal water excretion. AVP neurons are under feedback and feedforward regulation. Not only do they respond to disturbances in blood osmolality, but they are also rapidly suppressed and stimulated, respectively, by drinking and eating, which will ultimately decrease and increase osmolality. Here, we demonstrate that AVP neuron activity is regulated by multiple anatomically-and functionally-distinct neural circuits. Notably, presystemic regulation during drinking and eating are mediated by non-overlapping circuits that involve the lamina terminalis and hypothalamic arcuate nucleus, respectively. These findings reveal neural mechanisms that support differential regulation of AVP release by diverse behavioral and physiological stimuli.

Source: eLife

DOI: 10.7554/elife.66609

Authors: Angela Kim, Joseph C. Madara, Chen Wu, Mark L. Andermann, Bradford B. Lowell

Institutions: Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Neuroendocrine regulation and behavior

Subfield: Social Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500