Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND AIMS: This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hypertension in cirrhosis. METHODS: =1) between December 2018 and April 2019. A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017. After segmentation of the liver on fat-suppressed T1-weighted MRI maps, CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity. RESULTS: <0.01) for the training and validation cohorts, respectively. The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension (CSPH) was 0.81 and 0.9 in the training and validation cohorts, respectively. The intraclass correlation coefficients for assessing the inter- and intra-observer agreement were 0.846 and 0.841, respectively. CONCLUSIONS: A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG. Besides, this score could be used to detect CSPH in patients with cirrhosis.
Authors: Yanna Liu, Tianyu Tang, Necati Örmeci, Yifei Huang, Jitao Wang, Xiaoguo Li, Zhiwei Li, Weimin An, Dengxiang Liu, Chunqing Zhang, Changchun Liu, Jinqiang Liu, Chuan Liu, Guangchuan Wang, Cristina Mosconi, Alberta Cappelli, Antonio Bruno, Seray Akçalar, Emrecan Çelebioğlu, Evren Üstüner, Sadık Bilgiç, Zeynep Ellik, Özgün Ömer Asiller, Lei Li, Haijun Zhang, Ning Kang, Dan Xu, Ruiling He, Yan Wang, Yang Bu, Ye Gu, Shenghong Ju, Rita Golfieri, Xiaolong Qi
Institutions: Peking University, Nanfang Hospital, The Sixth People's Hospital of Shenyang, First Hospital of Lanzhou University, Southern Medical University, Zhongda Hospital Southeast University, Southeast University, Istanbul Health and Technology University, Xingtai People's Hospital, Shenzhen Third People’s Hospital, Chinese PLA General Hospital, Shandong University, Shandong Provincial Hospital, University of Bologna, Ankara University, Ningxia Hui Autonomous Region Peoples Hospital
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3202732659