Work

Searching for methyllysine-binding aromatic cages

Year: 2021

Type: article

Abstract: Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, and knowledge of the methyllysine binding mechanisms.

Source: Biochemical Journal

DOI: 10.1042/bcj20210106

Authors: Kendra R. Vann, Yashavantha L. Vishweshwaraiah, Nikolay V. Dokholyan, Tatiana G. Kutateladze

Institutions: University of Colorado Anschutz, Pennsylvania State University

Language: English

Topic: Cancer-related gene regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences