Work

Der Einfluss des Body Mass Index auf das Langzeitergebnis von Patienten mit Rektumkarzinom - eine monozentrische Studie

Year: 2020

Type: dissertation

Abstract: Background and objective The Body Mass Index (BMI) influences the long-term outcome in almost every tumor-disease. In patients with colorectal cancer a dose-response correlation was shown between BMI and cancer risk; however, little evidence exists for the influence of BMI on the long-term outcome of patients with rectal cancer. Material and Methods We assessed the impact of the BMI in the risk of local recurrence, distant metastasis and overall-survival in 612 patients between 2003 and 2010 after rectal cancer diagnosis and treatment at the University Hospital Erlangen. The patient cohort was divided in BMI-subgroups as defined by the World Health Organisation (WHO). Furthermore, the study population was split in two groups to meet the challenge of a society with increasing prevalence of obesity. A Cox-regression model was used to estimate the hazard ratio and multivariate risk of mortality and distant-metastases. Median follow-up time was 58 months. 2.3 Results and observations Patients with obesity class II or higher (BMI  35 kg/m2, n = 25) and patients with underweight (BMI <18,5 kg/m2, n = 5) had reduced overall survival (hazard ratio HR=1,6; 95% CI 0,9-2,7) as well as higher rates of distant metastases (hazard ratio HR=1,7; 95% CI 0,9-3,3) as compared to patients with normal bodyweight (BMI ≥18,5 - <25 kg/m2, n =209), overweight (BMI ≥25 - <30 kg/m2, n = 257) or obesity class I (BMI ≥30 - <35 kg/m2, n = 102). There were no significant differences for local recurrence. Conclusions We showed differences in survival rates and the presence of distant metastases (DM) depending on BMI values. Increased rates of Abdominoperineal excision (APE) and DM might be due to patient selection in our study cohort

Source: OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg)

Author: Maximilian Kalb

Language: German

Topic: Cancer Risks and Factors

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Friedrich-Alexander-Universität Erlangen-Nürnberg, Deutsche Forschungsgemeinschaft

Award: G3116251786

OpenAlex ID: W3202811986

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