Work

The transcriptomic revolution and radiation biology

Year: 2021

Type: article

Abstract: PURPOSE: This article will briefly review the origins and evolution of functional genomics, first describing the experimental technology, and then some of the approaches applied to data analysis and visualization. It will emphasize application of functional genomics to radiation biology, using examples from the author's work to illustrate several key types of analysis. It concludes with a look at non-coding RNA, alternative reading of the genome, and single-cell transcriptomics, some of the innovative areas that may help to shape future research in radiation biology and oncology. CONCLUSIONS: Transcriptomic approaches have provided insight into many areas of radiation biology and medicine, and innovations in technology and data analysis approaches promise continued contributions to radiation science in the future.

Source: International Journal of Radiation Biology

DOI: 10.1080/09553002.2021.1987562

Author: Sally A. Amundson

Institution: Columbia University Irving Medical Center

Language: English

Topic: Gene expression and cancer classification

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Computational Infrastructure, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Center for High-Throughput Minimally-Invasive Radiation Biodosimetry, Radiation Bystander Effects: Mechanisms, G4579778213, Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy, XBP1 Inhibition and STING activation for the treatment of cancer