Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for li-fraumeni syndrome
Year: 2021
Type: article
Abstract: BACKGROUND: -deficient human cancers, indicating that new animal models may complement current mouse models and better inform on human disease development. MATERIALS AND METHODS: knockout golden Syrian hamsters is described. RESULTS: heterozygous mutants develop a more restricted tumor spectrum, primarily lymphomas. CONCLUSIONS: deficiency leads to cancer in humans and can become a new model to test novel therapies.
Source: Journal of Carcinogenesis
Authors: Yaohe Wang, Zhongde Wang, RobertT Cormier, Jinxin Miao, Rong Li, ArnaudJ Van Wettere, Haoran Guo, Alexandru-Flaviu Tabaran, MGerald O'Sullivan, Timothy Carlson, PatriciaM Scott, Kuisheng Chen, Dongling Gao, Huixiang Li
Institutions: Utah State University, Henan University of Traditional Chinese Medicine, Queen Mary University of London, Zhengzhou University, Barts Cancer Institute, University of Minnesota, University of Minnesota, Duluth, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Masonic Cancer Center, First Affiliated Hospital of Zhengzhou University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W3202922211