Neuronal pericellular baskets: neurotransmitter convergence and regulation of network excitability
Year: 2021
Type: review
Abstract: A pericellular basket is a presynaptic configuration of numerous axonal boutons outlining a target neuron soma and its proximal dendrites. Recent studies show neurochemical diversity of pericellular baskets and suggest that neurotransmitter usage together with the dense, soma-proximal boutons may permit strong input effects on different timescales. Here we review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. As an example, we highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei. We propose that pericellular baskets represent convergence sites of competition or facilitation between neurotransmitter systems on downstream circuitry, especially in limbic brain regions, where pericellular baskets are widespread. Study of these baskets may enhance our understanding of monoamine regulation of memory, social behavior, and brain oscillations.
Source: Trends in Neurosciences
Authors: Rebecca A. Senft, Susan M. Dymecki
Institution: Harvard University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $6,700
Awards: Function-specific serotonergic neurons, discrete brain targets, and addiction, Genomic mechanisms of firing rate homeostasis, Developmental gene networks of 5HT neurons in addiction, aggression, and anxiety, Mapping serotonergic neuron subtypes protective for seizure-induced neurological and neurobehavioral changes, Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center
OpenAlex ID: W3203440362